什麼是 CBC,為什麼我們沒有聽說過它?

首先,什麼是CBC? CBC 是一種稱為大麻素 (CBC) 的次要大麻素。作為一個小大麻素是我們很少聽到 CBC 的原因之一。與大麻二酚 (CBD) 等其他主要大麻素相比,它的含量並不高。這可能會使提取成本高昂,這是您聽不到很多關於它的另一個原因,但您應該這樣做,因為 CBC 作為一種藥物有許多好處和應用。 CBC 的抗炎作用對於因炎症引起的疼痛和其他不適的人,以及導致炎症增加的自身免疫性疾病和其他幾種炎症性疾病的人來說,是一個主要的好處。一項研究直接著眼於 CBC 的藥理學潛力,發現 CBC 可有效引發“劑量依賴性抗炎作用”。 [1]   另一項發表在 Neurochemistry International 上的研究發現 CBC 是一種極好的大腦健康大麻素。它甚至與 CBD 和 CBG 進行了比較,結果表明 CBC 對神經乾祖細胞有積極的影響。這些細胞對於健康的大腦功能至關重要,CBC 增加了它們的活力,使 CBC 成為治療與腦細胞和大腦健康相關的疾病的潛在競爭者。 [2] 如果這還不足以讓您談論 CBC,那麼如果您發現 CBC 已被證明對治療癌症有效怎麼辦?事實上,研究幾種大麻素對乳腺癌抗腫瘤活性的效力的研究可能發現 CBD 在抑制腫瘤生長方面最有效,但 CBC 緊隨其後。這意味著 CBC 可以幫助阻止腫瘤生長。也許沒有CBD那麼多,但足以排在第二位。 [3] 儘管有這些,以及 CBC 的許多其他藥用益處,但它很有可能暫時繼續落後於更突出的大麻素,如 CBD。隨著大麻素醫學科學的繼續發展,隨著更多大麻素的真正潛力被發現,其他大麻素(如 CBC)將獲得更好的認可和討論。   References: 1- DeLong, G., et al., Pharmacological evaluation of the natural constituent of Cannabis sativa, cannabichromene and its modulation by Δ9-tetrahydrocannabinol. Drug and Alcohol Dependence. 2010. 112, (1-2) 126-133. https://www.sciencedirect.com/science/article/abs/pii/S0376871610002073 2- Shinjyo, N., et al., The effect of cannabichromene on adult neural stem/progenitor cells. Neurochemistry International. 2013. 63. (5) 432-437. https://www.sciencedirect.com/science/article/abs/pii/S0197018613002106 3- Ligresti, A. et al., Antitumor Activity of Plant Cannabinoids with Emphasis on the Effect of Cannabidiol on Human Breast Carcinoma. Journal of Pharmacology and Experimental Therapeutics. 318 (3) 1375-1387. https://jpet.aspetjournals.org/content/318/3/1375.long
2021-07-24

What is CBC and Why Don’t We Hear About it?

First off, what is CBC? CBC is a minor cannabinoid called cannabichromene (CBC). Being a minor cannabinoid is one of the reasons we don’t hear much about CBC. It isn’t found in very high percentages compared to other major cannabinoids like cannabidiol (CBD). This can make it costly to extract, which is another reason you don’t hear a lot about it, but you should, because CBC has many benefits and applications as a medicine. The anti-inflammatory effects of CBC are a major benefit for people with pain and other discomfort caused by inflammation, as well as those with auto-immune disorders that cause increased inflammation, and several other inflammatory conditions. One study looked directly at the pharmacological potential for CBC and found CBC effective in eliciting “dose-dependent anti-inflammatory effects“. [1] Another study, published in Neurochemistry International, discovered CBC to be an excellent cannabinoid for brain health. It was even compared to CBD and CBG, and the results showed CBC to have a positive effect on neural stem progenitor cells. These cells are essential for healthy brain functioning, and CBC increased their viability, making CBC a potential contender for treating disorders associated with brain cells and brain health. [2] If that isn’t enough to get you talking about CBC, then what if you found out that CBC has been shown to be effective for treating cancer? So effective in fact, research examining the potency of several cannabinoids on anti-tumor activity in breast cancer may have found CBD to be the most effective at inhibiting tumor growth, but CBC came in right behind it. This means CBC can help stop tumors from growing. Maybe not as much as CBD, but enough to get ranked in second place. [3] Despite these, and many other medicinal benefits of CBC, there’s a good chance it will continue to take a back seat to more prominent cannabinoids like CBD for the time being. As the science of cannabinoid medicine continues, other cannabinoids like CBC will gain ground to be better recognized and discussed as more of their true potential is discovered.   References: 1- DeLong, G., et al., Pharmacological evaluation of the natural constituent of Cannabis sativa, cannabichromene and its modulation by Δ9-tetrahydrocannabinol. Drug and Alcohol Dependence. 2010. 112, (1-2) 126-133. https://www.sciencedirect.com/science/article/abs/pii/S0376871610002073 2- Shinjyo, N., et al., The effect of cannabichromene on adult neural stem/progenitor cells. Neurochemistry International. 2013. 63. (5) 432-437. https://www.sciencedirect.com/science/article/abs/pii/S0197018613002106 3- Ligresti, A. et al., Antitumor Activity of Plant Cannabinoids with Emphasis on the Effect of Cannabidiol on Human Breast Carcinoma. Journal of Pharmacology and Experimental Therapeutics. 318 (3) 1375-1387. https://jpet.aspetjournals.org/content/318/3/1375.long
2021-07-24

CBD 如何抗衰老?

我們都希望永遠年輕,但我們知道這是不可能的。許多護膚產品可減少衰老跡象。但是,這些產品中有許多是無效的,可能會引起副作用。專家說,有效的替代品是CBD產品。讓我們來看看CBD如何幫助抗衰老。   可見老化的原因是什麼? 內部和外部因素都會導致老化。接觸後者的頻率會增加衰老跡象的出現,而內部因素早在20歲就開始出現。   衰老的內部因素 在皮膚水平上,衰老的內部因素包括自然的生物學過程,其特徵是我們的皮膚以及隨著時間的流逝,油脂分泌減少的油脂和皮膚中的膠原蛋白和彈性蛋白的流失。 膠原蛋白是一種結構蛋白,可保持我們的皮膚緊緻和緊實。隨著年齡的增長,他們的身體產生的膠原蛋白數量減少,導致皮膚變得更薄,更細膩。 彈性蛋白也是位於細胞外細胞基質中的關鍵蛋白質,可為我們的皮膚提供彈性。隨著年齡的增長,他們的皮膚失去彈性,這會導致皮膚下垂,這種作用由於重力而變得更加複雜。 油腺覆蓋了人體的整個皮膚,是人體最大的器官。這些腺體分泌油脂,使皮膚煥發光彩,看起來年輕。它們還可以吸收體內水分,使皮膚保持水分和健康。但是,在自然衰老過程中,這些腺體產生的油脂較少,導致皮膚失去水分,並隨著時間的推移變得更乾燥。在乾燥的皮膚中,衰老變得更加明顯。 在皮膚的下方更深處,還會發生一些生物變化,這些變化會加劇衰老的跡象,例如: 50後面部的骨質流失更加明顯,導致皮膚鬆弛。 下巴,鼻子,臉頰,眼睛周圍和太陽穴皮膚下的脂肪流失。這給了您在老年人中可能看到的獨特骨骼外觀。 鼻子周圍的軟骨損失會導致鼻尖出現特徵性下垂。     衰老的外部因素 除了衰老的內部生物學跡像外,還有導致衰老的外部因素。這些包括: 紫外線會分解皮膚中的彈性蛋白; 重力導致眼瞼和眉毛下垂,耳垂延長; 肥胖會使皮膚,頭髮和指甲因伸展而失去光澤; 每天的面部運動會導致30年代後臉部線條出現 吸煙,因為它會干擾皮膚的自然血液流動     CBD的抗衰老功效 CBD通過減緩膠原蛋白的流失並幫助皮脂腺分泌油脂,從而保持肌膚光彩,從而在逆轉衰老跡像中發揮積極作用。 研究表明,CBD是一種強大的抗氧化劑。已知抗氧化劑可對抗體內導致衰老和細胞變性的自由基。自由基導致皮膚中的膠原蛋白組織通過抵抗體內的自由基而更快地分解。CBD的抗氧化特性有助於顯著減緩膠原蛋白的流失,並幫助皮膚保持其自然繃緊和緊緻。 同樣,由於內源性大麻素通過向受體發送信息以通知腺體產生激素來確保荷爾蒙平衡,因此在確保皮脂腺也分泌油脂方面起了一定作用。因此,應用CBD或攝取CBD可以幫助增強皮膚中的皮脂腺,這些皮脂腺可能會失去其光澤和光澤。 這樣,CBD可以在阻礙導致衰老的最重要的兩個內部生物學功能中發揮關鍵作用,並幫助您長時間保持年輕,光滑的皮膚。   如何使用CBD來確保抗衰老? CBD是一種成熟的抗衰老化合物,可以口服和直接用於顯示衰老跡象的區域。但是,為了使CBD發揮最大作用,建議您主動遠離並保護自己免受導致衰老的外部影響。例如,吸煙會增加體內自由基的數量,這是導致衰老跡象提前出現的主要原因之一。 長時間暴露在陽光下也會由於暴露於紫外線而導致老化的跡象。使用防曬係數高的防曬霜以及太陽鏡和雨傘/帽子可以幫助保護面部和頸部免受強光照射,並減少臉上細紋和皺紋的出現。 建議至少喝八杯水,以確保身體水分充足。水促進彈性蛋白和膠原蛋白的產生。   CANNAMi CBD廣譜油 1000mg – 舒緩提升配方 主要功效: 緩和輕度抑鬱、焦慮和情緒障礙症狀 趕走失眠因子,改善睡眠質素 紓緩生活壓力及協助情緒管理 減輕中度慢性疼痛和炎症 控制食量和減輕體重 改善皮膚發炎及過敏、促進皮膚修復  
2021-03-16

How Does CBD Work For Anti-Aging?

We all want to live young forever but we know that it is not possible. Many skincare products offer to reduce the signs of aging. However, many of these products are ineffective and may cause side effects. Experts say that the effective alternative is CBD products. Let’s take a look at how CBD helps in anti-aging.   What are the causes of visible aging? Both internal and external factors cause aging. The frequency of exposure to the latter increases the appearance of signs of aging, while the internal factors start setting in as early as 20 years of age.   Internal factors of aging The internal factors of aging, at the skin level, include natural biological processes marked by the loss of collagen and elastin in our skin and the oil-producing glands producing lesser oil as the years pass by. Collagen is a structural protein that keeps our skins taut and firm. As a person ages, their bodies produce lesser amounts of collagen that leads to the skin becoming thinner and more delicate. Elastin is also a key protein located in the extracellular cell matrix, which renders elasticity to our skin. As people age, they lose elasticity in their skin, which results in the skin sagging, an effect that is compounded due to gravity. Oil-glands cover the entirety of the human skin, the largest organ in the human body. These glands secrete oil that makes the skin glow and look youthful. They also trap moisture in the body and keeps the skin looking hydrated and healthy. However, in the natural process of aging, these glands produce lesser oil, which leads the skin to lose its moisture and over time become drier. Aging becomes more noticeable in dry skin. Deeper down, below the skin, some more biological changes occur that add to the signs of aging, such as: Bone loss on the face becomes more prominent post 50, resulting in slack skin. Loss of fat under the skin in chin, nose, cheeks, around the eyes, and temples. This gives the face the distinct skeletal appearance that you might see in the elderly. Loss in cartilage around the nose leads to characteristic droop at the nose tip.     External factors of aging Apart from the internal biological signs of aging, there are external factors that lead to aging, as well. These include: UV rays that break down the elastin in the skin; Gravity which causes drooping eyelids and eyebrows, lengthening of earlobes; Obesity which makes the skin, hair, and nails lose their luster by stretching the skin; Daily facial movements leading to the appearance of lines on the face post 30s Smoking, as it interferes with the natural blood flow to the skin     CBD’s anti-aging benefits CBD plays an active role in reversing the signs of aging by slowing down the loss of collagen and also aiding the sebaceous glands secrete oil, thus maintaining glowing skin. Research has shown that CBD acts as a powerful antioxidant. Antioxidants are known to fight free radicals in the body that cause aging and cell degeneration. Free radicals lead to the collagen tissues in the skin break down faster by countering free radicals in the body. The antioxidant properties of CBD help slow collagen loss down significantly and help the skin retain its natural taut and firmness. Also, since endocannabinoids play a role in ensuring hormonal balance by sending messages to the receptors to signal glands to produce hormones, it is somewhat responsible for ensuring that the sebaceous gland secretes oil as well. Therefore, applying CBD or ingesting it can help boost the sebaceous glands in the skin, which might be losing its glow and luster. In this way, CBD can play a crucial role in hindering two of the most crucial, internal biological functions that lead to aging and help you retain your younger, smooth skin for a longer period.   How to use CBD to ensure anti-aging? CBD has been an established anti-aging compound that can be taken both orally and applied directly to areas showing signs of aging. However, for CBD to work at its best, it is recommended to actively stay away and protect oneself from the external influences that cause aging. For example, smoking increases the number of free radicals in the body, which is one of the major causes that leads to the early onset of signs of aging. Exposure to the sun for long durations also leads to signs of aging due to exposure to UV rays. Using sun protectors with high SPF values along with sunglasses and umbrellas/hats can help protect the face and neck regions from the harsh rays and reduce the occurrence of fine lines and wrinkles on the face. Drinking at least eight glasses of water is recommended to ensure that the body is hydrated. Water boosts the production of both elastin and collagen.   CANNAMi Broad Spectrum CBD Oil 1000mg – Relief & Enhance Main Functions: Relieve symptoms of mild depression, anxiety and mood disorders Improve insomnia and sleep quality Relieve pressure and assist emotional management Reduce moderate chronic pain and inflammation Control Food Intake and Reduce Weight Improve Skin Inflammation and Allergies, Promote Skin Repair
2021-03-16

感到壓力?焦慮?鬱悶?

感到壓力?焦慮的?鬱悶? CBD可以幫助您調節步伐,緩解焦慮並減輕抑鬱症的症狀。   每個人都會經歷壓力和情緒不時波動-但是“健康壓力”和“不健康壓力”之間有明顯的區別。   當今世界,太多的人每天都經歷著情緒的過山車,殘酷的壓力或焦慮。   CBD油對焦慮,壓力和抑鬱的好處 CBD是一種很好的補充品,可與壓力,焦慮或情緒障礙一起使用。   這種獨特的化合物與人體中稱為內源性大麻素的系統相互作用,該系統在應激反應和情緒調節中起關鍵作用。   最佳的用於焦慮和情緒障礙的CBD油由全光譜或廣譜提取物製成,可提供相對較高的CBD濃度(至少30 mg / mL),並已通過質量和效能獨立測試。   有些人會立即體驗到CBD油的好處,而其他人則需要幾天或幾週的時間服用這種油,然後才能有明顯的區別。   使用CBD時要有耐心和耐心,這一點很重要。監視您的感覺並採取其他措施來減輕焦慮。   CBD油對焦慮,抑鬱和情緒障礙的益處包括: •通過促進GABA活性來鎮定思維 •調節大腦中的血清素和多巴胺水平 •減少腦部炎症 •促進更多恢復性睡眠 •降低皮質醇水平 •保護身體免受氧化損傷   1. CBD油通過促進GABA活性來鎮靜精神 GABA是大腦的主要神經抑製劑-這意味著它的任務是成為大腦的剎車踏板。當我們感到焦慮或煩躁時,由GABA來減慢速度並使我們回到更正常,更放鬆的狀態。   焦慮症患者經常會遇到GABA問題。如果沒有這種化合物來控制大腦活動,我們會感到焦慮,驚恐發作,失眠等。   CBD已顯示與大腦中的GABA受體相互作用[34]。   這種相互作用類似於普通處方焦慮藥物如Xanax或Valium的作用,但作用力要小得多。 CBD不是直接激活這些受體,而是提高了自然產生的GABA與受體結合併發揮其作用的能力。   結果是焦慮水平顯著降低,並帶來其他好處,如肌肉鬆弛和改善睡眠發作。   2. CBD調節5-羥色胺和多巴胺 血清素,多巴胺和去甲腎上腺素都是與調節情緒和精神狀態有關的關鍵神經遞質。這些神經遞質的失衡會導致焦慮和抑鬱。   CBD已顯示出刺激血清素受體(5HT1A)的作用[30],這會導致大腦中血清素活性的增加。 5HT1A受體活性低與驚恐發作和焦慮有關[31]。   多巴胺在調節焦慮水平中也起著關鍵作用。小鼠中低的多巴胺水平與廣泛性焦慮症狀的增加相關[32]。已經證明,CBD對多巴胺受體具有輕度的刺激作用[9],它可以增加大腦中的多巴胺水平並減輕焦慮症狀。   3. CBD減少腦部炎症 最近新發現的證據表明,神經炎症(大腦炎症)是引起焦慮和抑鬱的主要原因[35]。   大腦中的化學平衡必須保持在嚴格的控制範圍內。我們血液中的化合物可能會干擾這種微妙的平衡,因此,襯在我們大腦血管中的特殊膜(稱為血腦屏障)可防止有害分子直接進入大腦。   如果該內襯發炎,則可能會損壞該屏障的完整性。血液中的化合物進入大腦,並影響5-羥色胺,多巴胺,去甲腎上腺素,GABA,谷氨酸等神經遞質-可能導致焦慮。   CBD已被證明可以減少神經炎症並增強由炎症過程引起的受損神經細胞的再生[36]。   4. CBD促進更長,更恢復性的睡眠 睡眠不足是焦慮的另一個常見原因。 2006年的一項研究表明,僅僅剝奪一夜的睡眠第二天就會導致焦慮評分明顯升高[37]。   焦慮本身是睡眠不足的常見原因-導致自我永存的負面反饋。高焦慮水平導致較低的睡眠質量,從而導致更多的焦慮。   通過在白天管理焦慮症狀並改善夜間睡眠質量,可以使用CBD來打破週期。   一篇評論文章分析了超過2000名參與者的研究結果,以探討CBD和其他大麻素對睡眠的影響。該研究得出的結論是,參與這些臨床研究的約50%的患者的睡眠質量和持續時間明顯增加[38]。   5. CBD降低皮質醇水平 焦慮與我們的壓力反應(稱為“戰鬥或逃跑”反應)直接相關。   壓力始於包括下丘腦和垂體在內的大腦區域。大腦的這一部分負責控制激素從體內其他器官(包括腎上腺)的釋放。這兩個器官之間的連接稱為HPA軸(下丘腦-垂體軸)。   當我們面對壓力大的情況(例如與飢餓的動物面對面或感到即將到來的最後期限的壓力)時,下丘腦向腎上腺發出信號,開始釋放皮質醇。   皮質醇負責引起我們認為是壓力的變化。它會增加心率和血壓,刺激思想,並迫使血糖水平增加。   通常,當緩解壓力時,下丘腦停止告訴腎上腺分泌皮質醇,並且水平恢復正常。   但是,許多人長時間處於“壓力”狀態。皮質醇繼續激活應激反應,導致與焦慮相關的症狀。   CBD和其他大麻素已被證明可通過其對內源性大麻素系統的調節來調節下丘腦[39]。下丘腦敏感性的提高導致皮質醇水平的顯著降低。   6. CBD防止氧化損傷 壓力造成如此多破壞的主要方法之一是通過所謂的氧化損傷。   較高的血糖和增加的代謝活動壓力引起的原因可導致自由基產物的積聚,從而破壞整個身體的組織。   通常,當我們在放鬆狀態下進入休息和消化模式時,這種情況會清除,但是,當然,當我們長時間承受壓力時,這些自由基仍然存在。   CBD油中的抗氧化劑含量很高[48],可幫助中和自由基分子並保護人體免受其破壞性影響。     CBD油對於焦慮 每個人在生活中的某些時候都經歷過焦慮。在某種程度上,感到焦慮是完全正常的。   經常感到焦慮會導致其他各種健康問題,並使其難以履行日常職責。   健康的焦慮可以幫助我們應對各種危險,例如與飢餓的動物面對面,打架或站在離地面1000英尺的壁架上。焦慮會幫助我們逃避危險,打架或更加緊緊地避免跌倒。   當我們過於頻繁地感到焦慮,或者我們感到不適的程度時,就會發生焦慮症。   例如,社交焦慮症的特徵是圍繞害怕被他人審判的嚴重,使人衰弱的焦慮。這種形式的焦慮會使患者很難公開露面,與朋友見面或以任何方式與陌生人互動。   不同的焦慮症包括: •廣泛性焦慮症(GAD) •強迫症(OCD) •恐慌症 •特定恐懼症 •社交焦慮症(SAD) •選擇性關愛 •分離焦慮症 •創傷後應激障礙(PTSD)   引起焦慮的原因是什麼? 焦慮有很多原因。實際上,任何引發壓力的事物都可能導致焦慮。最常見的原因是財務問題,失去朋友或家人,診斷出患有健康失調,攝入過多的興奮劑和缺乏睡眠。   焦慮的原因可能包括: •飲酒 •咖啡因攝入量 •心髒病 •無法有效應對壓力 •營養缺乏 •娛樂性吸毒和成癮 •藥物的副作用 •睡眠不足 •抽煙 •創傷史   焦慮症有哪些症狀? 每個人的焦慮症狀都不同。最常見的症狀是心跳加快,血壓升高,注意力不集中,情緒變化和失眠。   症狀可能會在一整天內出現或消失,或者整天保持不變。   焦慮症的常見症狀包括: •心跳加速 •高血壓 •困惑 •頭暈 •耳鳴(耳鳴) •情緒變化 •注意力不集中 •失眠 •消化系統疾病(便秘或腹瀉) •換氣過度 •經常感冒/流感   藥物性焦慮藥物對我們的健康有害嗎? 醫生可以選擇多種處方藥來治療焦慮症。儘管這些藥物在短期內有效,但許多藥物會導致嚴重的副作用,依賴性以及長期治療後容易被濫用。   用於治療焦慮症的最常見藥物是苯二氮卓類藥物(例如Xanax)。這些藥物以類似於CBD的方式靶向GABA受體,但作用更強。   在短短的兩週內,人體將開始對苯二氮卓類藥物形成依賴性。發生這種情況時,GABA受體會適應藥物,以恢復平衡。 GABA受體被隱藏起來,以降低藥物的作用。   如果不再使用該藥物,我們將失去激活GABA的能力(因為我們對藥物的反應可用的受體較少)。其結果與促使我們一開始服用的症狀相同(焦慮和失眠)。我們變得越來越依賴於將藥物放入我們的系統中,從而避免焦慮發作。   簡而言之,短期服用處方焦慮藥是安全的,但是使用超過2週,它們可能會產生相反的效果-一旦藥物開始老化,就會引起嚴重的驚恐發作和焦慮。   常見的處方焦慮藥物包括: •阿普唑侖(Xanax) •氯硝西am(可洛平) •氯氮卓(鋰) •地西p(安定) •勞拉西m(Ativan) •替馬西m(Restoril) •三唑侖(Halcion)   CBD是焦慮症狀的絕佳補充,但與其他方法結合使用時效果最好。有針對性的,多方面的方法始終會比單獨的任何療法(包括CBD)產生更大的影響。   您可以採取其他一些措施來減輕焦慮: •飲食均衡,避免食用高糖或加工食品 •確定焦慮的原因,並採取措施減少其影響 •拜訪輔導員以解決潛在的創傷 •與CBD油一起服用其他焦慮補充劑(卡瓦,L-茶氨酸,鎂) •優先安排睡眠(每晚至少爭取8小時不間斷睡眠) •定期運動(即使每天僅20分鐘也能減輕焦慮水平) •練習冥想或瑜伽(每天練習10 – 30分鐘)     CBD油對於抑鬱症 抑鬱症是最常見的情緒障礙-根據世界衛生組織的數據,全世界每年影響多達3億人。   抑鬱症有幾種不同的類型,其特徵是存在其他症狀以及症狀持續的時間長短。所有形式的抑鬱症都涉及慢性情緒低落和動機。其他症狀可能包括疲勞,慢性疼痛,失眠,焦慮或性慾低下。   抑鬱症的嚴重程度分為三個級別: 1.輕度抑鬱-涉及低等級的興趣喪失或動機低下。 2.中度抑鬱-涉及大量的動機和低能量消耗,可能會干擾或可能不會干擾日常工作。 3.嚴重的抑鬱-可能包括自殺念頭或完全失去動力。   CBD對抑鬱症的好處 有幾種方法可以使用CBD緩解抑鬱症。最重要的是通過CBD的抗炎作用,尤其是在神經炎症(大腦炎症)方面。炎症被認為是導致抑鬱的最常見原因之一[24]。   CBD還可以保護海馬免受損害-這是大腦中負責調節情緒的區域,並且是抑鬱症患者大腦中最早顯示出損害跡象的大腦區域之一。   CBD油治療抑鬱症的好處包括: •減少腦部炎症 •保護大腦免受損害和退化 •增加大腦中的anandamide活性 •調節血清素,多巴胺和去甲腎上腺素 •支持健康的睡眠   CBD油用於其他情緒障礙 情緒障礙(也稱為情感障礙)是影響我們調節和維持情緒的神經系統疾病的集合。   情緒障礙有許多種,而CBD的每一種都略有不同。   CBD對以炎症或自身免疫性疾病為基礎的情緒障礙或情緒異常活躍的人(如躁鬱症或躁狂症)影響最大。對於抑鬱症,CBD可以緩解常見的副作用,例如失眠或低能量。   什麼導致情緒障礙? •物質濫用 •慢性壓力 •喪親 •藥物副作用 •神經退行性疾​​病 •營養缺乏 •遺傳易感性 •創傷後壓力 •慢性焦慮    以下是最常見的情緒障礙類型,以及CBD可能如何提供幫助:   1.躁鬱症  躁鬱症是一種神經系統疾病,涉及情緒的極端變化-從深度抑鬱到欣快躁狂,以及介於兩者之間的一切。   躁鬱症無法治愈,針對這種疾病的藥物療效往往不佳。   目前,一項大型臨床試驗正在研究CBD作為雙相型個體治療計劃的潛在益處。儘管這項研究要到2020年才能完成,但對於CBD來說,結果似乎很有希望。   CBD對雙相情感障礙的益處 CBD對雙相情感障礙可能是有效的-但是,雙相情感障礙對每個人的影響都不同。對一個人可能有效的措施可能會使另一個人的症狀惡化。因此,在嘗試之前,與您的醫生或心理學家討論使用CBD的重要性。   如果您決定使用CBD,請始終以最小的劑量開始,然後逐漸從那裡逐漸累積,以了解它如何影響您的症狀。   2. 躁狂 躁狂症(也稱為躁狂綜合徵)是一種嚴重的疾病,涉及異常高的能量水平,欣快感和頻繁的焦慮發作。這與抑鬱症相反,但也可能使人衰弱。   躁狂綜合症會導致暴力,侵略,易怒和妄想增加。這種情況可能很危險,使人們變得魯ck,受傷的風險更高。   CBD對躁狂症的好處 由於擔心病情惡化,應謹慎使用CBD。躁狂症是一種嚴重疾病,需要訓練有素的醫療專業人員的照顧。   躁狂的原因因人而異,儘管有報導稱人們使用CBD有效治療該症狀-大量關於大麻產品的報導也使症狀惡化。   3.低躁狂症 低躁狂症類似於躁狂症,但症狀較輕。它介於抑鬱和躁狂之間。   躁狂症的症狀包括長時間的欣快感和抑制力,但沒有躁狂症嚴重。   CBD對低躁狂症的益處 CBD可用於支持躁狂症的某些副作用,例如失眠和焦慮。與躁狂症類似,在這種情況下應謹慎使用CBD。總是從小劑量開始逐漸增加。   當您知道它對您的影響如何並且您確認它不會使症狀惡化時,請嘗試增加劑量。   4.季節性情感障礙(SAD) 季節性情感障礙(SAD)是一種由於缺乏陽光照射而引起的情緒障礙。之所以稱為季節性疾病,是因為它在白天白天最低的冬季的北部氣候中尤為普遍。同時,這些地方的寒冷天氣意味著居住在那裡的人們往往會掩蓋大部分裸露的皮膚,從而進一步限制了紫外線對皮膚的暴露。   當太陽光照射到皮膚上時,它會引起酶促反應,從而產生維生素D(維生素D是我們情緒中的關鍵調節劑)。   對於季節性情感障礙,最好的治療方法是定期暴露於陽光或其他紫外線輻射下,並補充維生素D。   CBD對季節性情感障礙(SAD)的好處 通過減輕疾病的許多相關副作用,例如失眠,免疫力低下,抑鬱和焦慮,CBD和THC均可用於這種疾病。但是,仍需要補充維生素D和暴露於紫外線下才能達到最佳效果。   1. CANNAMi CBD廣譜油 500mg – 平衡保健配方 主要功效: 促進自然睡眠規律,改善睡眠質素 紓緩生活壓力及協助情緒管理 減輕慢性疼痛和炎症 保持身體和心靈平衡健康   2. CANNAMi CBD廣譜油 1000mg – 舒緩提升配方 主要功效: 緩和輕度抑鬱、焦慮和情緒障礙症狀 趕走失眠因子,改善睡眠質素 紓緩生活壓力及協助情緒管理 減輕中度慢性疼痛和炎症 保持身體和心靈平衡健康   3. CANNAMi CBD廣譜油 1500mg – 全效強力配方 主要功效: 緩和抑鬱、焦慮和情緒障礙症狀 紓緩嚴重失眠,調節睡眠週期和方式 紓緩各項嚴重疼痛和炎症 改善皮膚發炎及過敏、促進皮膚修復 調節大腦減少癲癇發作   4. CANNAMi CBG廣譜油 1000mg – 精準舒緩配方 主要功效: 有效改善及舒緩因治療頑疾後所引致的食慾問題 紓緩抑鬱、焦慮和情緒障礙症狀 有效治療青光眼 有效減少炎症性腸病的炎症特徵 有效抑製耐藥性細菌, 如金黃色葡萄球菌 減輕慢性疼痛和炎症   5. CANNAMi CBD廣譜油 500mg – 舒壓安眠配方 主要功效: 促進自然睡眠規律,改善睡眠質素 紓緩情緒壓力及協助情緒管理 減輕慢性疼痛和炎症 保持身體和心靈平衡健康   本文引用的參考文獻 Manrique-Garcia, E., Zammit, S., Dalman, C., Hemmingsson, T., & Allebeck, P. (2012). Cannabis use and depression: a longitudinal study of a national cohort of Swedish conscripts. BMC Psychiatry, 12(1), 112. Banerjee, S. P., Snyder, S. H., & Mechoulam, R. A. P. H. A. E. L. (1975). Cannabinoids: influence on neurotransmitter uptake in rat brain synaptosomes. Journal of Pharmacology and Experimental Therapeutics, 194(1), 74-81. Réus, G. Z., Stringari, R. B., Ribeiro, K. F., Luft, T., Abelaira, H. M., Fries, G. R., … & Crippa, J. A. (2011). Administration of cannabidiol and imipramine induces antidepressant-like effects in the forced swimming test and increases brain-derived neurotrophic factor levels in the rat amygdala. Acta neuropsychiatrica, 23(5), 241-248. Campos, A. C., Moreira, F. A., Gomes, F. V., Del Bel, E. A., & Guimaraes, F. S. (2012). Multiple mechanisms involved in the large-spectrum therapeutic potential of cannabidiol in psychiatric disorders. Philosophical Transactions of the Royal Society B: Biological Sciences, 367(1607), 3364-3378. Zuardi, A. W., Cosme, R. A., Graeff, F. G., & Guimarães, F. S. (1993). Effects of ipsapirone and cannabidiol on human experimental anxiety. Journal of psychopharmacology, 7(1), 82-88. de Souza Crippa, J. A., Zuardi, A. W., Garrido, G. E., Wichert-Ana, L., Guarnieri, R., Ferrari, L., … & McGuire, P. K. (2004). Effects of cannabidiol (CBD) on regional cerebral blood flow. 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Cannabidiol inhibitory effect on marble-burying behaviour: involvement of CB1 receptors. Behavioural pharmacology, 21(4), 353-358. Esposito, G., De Filippis, D., Maiuri, M. C., De Stefano, D., Carnuccio, R., & Iuvone, T. (2006). Cannabidiol inhibits inducible nitric oxide synthase protein expression and nitric oxide production in β-amyloid stimulated PC12 neurons through p38 MAP kinase and NF-κB involvement. Neuroscience letters, 399(1-2), 91-95. Esposito, G., Scuderi, C., Valenza, M., Togna, G. I., Latina, V., De Filippis, D., … & Steardo, L. (2011). Cannabidiol reduces Aβ-induced neuroinflammation and promotes hippocampal neurogenesis through PPARγ involvement. PloS one, 6(12), e28668. Ludányi, A., Erőss, L., Czirják, S., Vajda, J., Halász, P., Watanabe, M., … & Katona, I. (2008). Downregulation of the CB1 cannabinoid receptor and related molecular elements of the endocannabinoid system in epileptic human hippocampus. Journal of Neuroscience, 28(12), 2976-2990. Samuels, B. A., & Hen, R. (2011). Neurogenesis and affective disorders. European Journal of Neuroscience, 33(6), 1152-1159. Hill, M. N., & Gorzalka, B. B. (2009). The endocannabinoid system and the treatment of mood and anxiety disorders. CNS & Neurological Disorders-Drug Targets (Formerly Current Drug Targets-CNS & Neurological Disorders), 8(6), 451-458., 8(6), 451-458. Huestis, M. A., Gorelick, D. A., Heishman, S. J., Preston, K. L., Nelson, R. A., Moolchan, E. T., & Frank, R. A. (2001). Blockade of effects of smoked marijuana by the CB1-selective cannabinoid receptor antagonist SR141716. Archives of general psychiatry, 58(4), 322-328. Wise, R. A., & Bozarth, M. A. (1985). Brain mechanisms of drug reward and euphoria. Psychiatric medicine, 3(4), 445-460. Cheer, J. F., Wassum, K. M., Sombers, L. A., Heien, M. L., Ariansen, J. L., Aragona, B. J., … & Wightman, R. M. (2007). Phasic dopamine release evoked by abused substances requires cannabinoid receptor activation. 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M., & File, S. E. (2005). Endocannabinoid system and stress and anxiety responses. Pharmacology Biochemistry and Behavior, 81(2), 331-342. Hurley, L. L., & Tizabi, Y. (2013). Neuroinflammation, neurodegeneration, and depression. Neurotoxicity research, 23(2), 131-144. Zuardi, A. W., Shirakawa, I., Finkelfarb, E., & Karniol, I. G. (1982). Action of cannabidiol on the anxiety and other effects produced by Δ 9-THC in normal subjects. Psychopharmacology, 76(3), 245-250. Zuardi, A. W., Cosme, R. A., Graeff, F. G., & Guimarães, F. S. (1993). Effects of ipsapirone and cannabidiol on human experimental anxiety. Journal of psychopharmacology, 7(1_suppl), 82-88. Banerjee, S. P., Snyder, S. H., & Mechoulam, R. A. P. H. A. E. L. (1975). Cannabinoids: influence on neurotransmitter uptake in rat brain synaptosomes. Journal of Pharmacology and Experimental Therapeutics, 194(1), 74-81. Crippa, J. A. S., Derenusson, G. N., Ferrari, T. B., Wichert-Ana, L., Duran, F. L., Martin-Santos, R., … & Filho, A. S. (2011). Neural basis of anxiolytic effects of cannabidiol (CBD) in generalized social anxiety disorder: a preliminary report. Journal of Psychopharmacology, 25(1), 121-130. Bakas, T., Van Nieuwenhuijzen, P. S., Devenish, S. O., McGregor, I. S., Arnold, J. C., & Chebib, M. (2017). The direct actions of cannabidiol and 2-arachidonoyl glycerol at GABAA receptors. Pharmacological research, 119, 358-370. Sales, A. J., Crestani, C. C., Guimarães, F. S., & Joca, S. R. (2018). Antidepressant-like effect induced by Cannabidiol is dependent on brain serotonin levels. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 86, 255-261. Charney, D. S., Woods, S. W., Goodman, W. K., & Heninger, G. R. (1987). Serotonin function in anxiety. Psychopharmacology, 92(1), 14-24. Zweifel, L. S., Fadok, J. P., Argilli, E., Garelick, M. G., Jones, G. L., Dickerson, T. M., … & Palmiter, R. D. (2011). 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M., Fries, G. R., … & Crippa, J. A. (2011). Administration of cannabidiol and imipramine induces antidepressant-like effects in the forced swimming test and increases brain-derived neurotrophic factor levels in the rat amygdala. Acta neuropsychiatrica, 23(5), 241-248. R de Mello Schier, A., P de Oliveira Ribeiro, N., S Coutinho, D., Machado, S., Arias-Carrión, O., A Crippa, J., … & C Silva, A. (2014). Antidepressant-like and anxiolytic-like effects of cannabidiol: a chemical compound of Cannabis sativa. CNS & Neurological Disorders-Drug Targets (Formerly Current Drug Targets-CNS & Neurological Disorders), 13(6), 953-960. Cowen, P. J., & Browning, M. (2015). What has serotonin to do with depression?. World Psychiatry, 14(2), 158-160. Smith, K. A., Fairburn, C. G., & Cowen, P. J. (1997). Relapse of depression after rapid depletion of tryptophan. The Lancet, 349(9056), 915-919. Wichers, M. C., Koek, G. H., Robaeys, G., Verkerk, R., Scharpe, S., & Maes, M. (2005). 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2021-02-25

Feeling Stressed? Anxious? Depressed?

Feeling Stressed? Anxious? Depressed? CBD may help regulate your stress, ease anxiety, and alleviate symptoms of depression.   Everyone experiences stress and mood swings from time to time — but there’s a clear distinction between “healthy stress” and “unhealthy stress”.   Too many people in today’s world experience a rollercoaster of emotions, and crippling stress or anxiety on a daily basis.   Benefits of CBD Oil For Anxiety, Stress & Depression CBD is a great supplement to take alongside stress, anxiety, or mood disorders.   This unique compound interacts with a system in the body known as the endocannabinoid system — which plays a key role in the stress response and regulation of our mood.   The best CBD oils for anxiety and mood disorders are made from full-spectrum or board-spectrum extracts, provide relatively high concentrations of CBD (at least 30 mg/mL), and have been independently tested for quality and potency.   Some people experience the benefits of CBD oils immediately — others need to take the oil for several days or weeks before there’s any noticeable difference.   It’s important to be patient and persistent when using CBD. Monitor how your feeling and take other measures to help alleviate anxiety.   The benefits of CBD oil for anxiety, depression, & mood disorders include: Calms the mind by boosting GABA activity Regulates serotonin & dopamine levels in the brain Reduces brain inflammation Promotes more restorative sleep Reduces cortisol levels Protects the body from oxidative damage   1. CBD Oil Calms The Mind By Promoting GABA Activity GABA is the brain’s primary neuroinhibitor — which means it’s tasked with being the brake pedal for the mind. When we become anxious or agitated, it’s up to GABA to slow us down and bring us back to a more normal, relaxed state.   Anxiety sufferers often experience a problem with GABA. Without this compound keeping brain activity in check, we experience bouts of anxiety, panic attacks, insomnia, and more.   CBD has been shown to interact with GABA receptors in the brain [34].   The interaction is similar to the effects of common prescription anxiety medications like Xanax or Valium, but with much less force. Instead of directly activating these receptors, CBD helps improve the ability for naturally-produced GABA to bind to the receptor and exert its effect.   The result is a dramatic reduction in anxiety levels as well as other benefits like muscle relaxation and improved sleep onset.   2. CBD Regulates Serotonin & Dopamine Serotonin, dopamine, and norepinephrine are all key neurotransmitters involved with regulating mood and mental state. Imbalances with these neurotransmitters can lead to anxiety and depression.   CBD has been shown to stimulate the serotonin receptors (5HT1A) [30]— which leads to increased serotonin activity in the brain. Low 5HT1A receptor activity has been correlated with panic attacks and anxiety [31].   Dopamine also plays a key role in regulating anxiety levels. Low dopamine levels in mice are correlated with an increase in generalized anxiety symptoms [32]. CBD has been shown to have a mild stimulating effect on the dopamine receptors [9] — which increases dopamine levels in the brain and alleviates anxiety symptoms.   3. CBD Reduces Inflammation In The Brain New evidence has recently come to light implicating neuroinflammation (inflammation in the brain) to be a major underlying cause for anxiety and depression [35].   The chemical balance in the brain must be kept within a tight range of controls. Compounds in our blood may interfere with this delicate balance, so a special membrane lining the blood vessels in our brain (called the blood-brain barrier) works to keep unwanted molecules from being able to enter the brain directly.   If this lining becomes inflamed, it can result in damage to the integrity of this barrier. Compounds in the blood enter the brain and affect neurotransmitters like serotonin, dopamine, norepinephrine, GABA, glutamate, and more — potentially leading to anxiety.   CBD has been shown to reduce neuroinflammation and enhance the regeneration of damaged nerve cells caused by the inflammatory process [36].   4. CBD Promotes Longer, More Restorative Sleep Sleep deprivation is another common cause of anxiety. A 2006 study showed that just one night of sleep deprivation resulted in significantly higher anxiety scores the following day [37].   Anxiety itself is a common cause of insufficient sleep — resulting in a self-perpetuating negative feedback look. High anxiety levels lead to lower sleep quality, which leads to more anxiety.   CBD can be used to break the cycle by managing anxiety symptoms during the day and improving sleep quality at night.   A review paper analyzed the results of research on over 2000 participants to explore the impact of CBD and other cannabinoids on sleep. The study concluded that there was a clear increase in sleep quality and duration in around 50% of the patients taking part in these clinical studies [38].   5. CBD Reduces Cortisol Levels Anxiety is directly related to our stress response — called the “fight or flight” response.   Stress begins with a region of the brain that includes the hypothalamus and pituitary gland. This part of the brain is tasked with controlling the release of hormones from other organs in the body, including the adrenal glands. The connection between these two organs is referred to as the HPA-axis (hypothalamic-pituitary axis).   When we’re faced with a stressful situation — such as coming face to face with a hungry animal or feeling the pressure of an upcoming deadline — the hypothalamus sends a signal to the adrenal glands to start releasing cortisol.   Cortisol is responsible for inducing the changes we perceive as stress. It increases heart rate and blood pressure, stimulates the mind, and forces blood sugar levels to increase.   Usually, when the stressful situation is mitigated, the hypothalamus stops telling the adrenal glands to secrete cortisol, and levels go back to normal.   However, many people remain in the “stress” state for long periods of time. Cortisol continues to activate the stress response, leading to symptoms associated with anxiety.   CBD and other cannabinoids have been shown to modulate the hypothalamus through its effects on the endocannabinoid system [39]. Improving the sensitivity of the hypothalamus leads to a dramatic reduction in cortisol levels.   6. CBD Protects Against Oxidative Damage One of the main ways stress causes so much destruction is through something called oxidative damage.   Higher blood sugar and increased metabolic activity stress causes can lead to a buildup of free radical products which can damage tissues all over the body.   Normally this is cleared up when we enter the rest and digest mode in a state of relaxation, but of course, when we’re stressed for long periods of time these free radicals persist.   CBD oil is high in antioxidant compounds [48] that help neutralize free radical molecules and protects the body from their damaging influence.     CBD Oil For Anxiety Everybody has experienced anxiety at some point in their lives. It’s completely normal to feel anxious — to an extent.   Feeling anxious too often can lead to a variety of other health issues and makes it difficult to carry out daily responsibilities.   Healthy anxiety helps us deal with dangers — such as coming face to face with a hungry animal, getting into a fight, or standing on a ledge a thousand feet from the ground below. Our anxiety helps us run away from danger, win a fight, or hold on more tightly to avoid falling.   Anxiety disorders happen when we feel anxiety too often, or we experience a level of anxiety inappropriate for the situation.   For example, social anxiety disorder is characterized by severe, debilitating anxiety around the fear of being judged by others. This form of anxiety can make it hard for sufferers to go out in public, visit with friends, or interact with strangers in any way.   Different Anxiety Disorders Include: Generalized anxiety disorder (GAD) Obsessive compulsive disorder (OCD) Panic disorder Specific phobias Social anxiety disorder (SAD) Selective mutism Separation anxiety disorder Post Traumatic Stress Disorder (PTSD)   What Causes Anxiety? Anxiety has many causes. Virtually anything that triggers stress can result in anxiety. The most common causes are financial concerns, loss of a friend or family member, diagnosis with a health disorder, excessive stimulant intake, and lack of sleep.   Causes of Anxiety May Include: Alcohol use Caffeine intake Heart disease Inability to effectively cope with stress Nutritional deficiencies Recreational drug use & addiction Side effects of medications Sleep deprivation Smoking Traumatic history   What Are The Symptoms of Anxiety? The symptoms of anxiety are different for everybody. The most common symptoms are increased heart rate, elevations in blood pressure, loss of focus, changes in mood, and insomnia.   Symptoms can come and go throughout the day, or remain consistent all day long.   Common symptoms of anxiety disorders include: Rapid heartbeat High blood pressure Confusion Dizziness Tinnitus (ringing in the ears) Mood changes Poor concentration Insomnia Digestive disturbances (constipation or diarrhea) Hyperventilation Frequent cold/flu   Are Pharmaceutical Anxiety Medications Dangerous to Our Health? There are a variety of prescription medications doctors can choose from to treat anxiety. While these medications work in the short term, many of them lead to severe side effects, dependency, and potential for abuse with long term treatment.   The most common class of drugs used to treat anxiety are the benzodiazepines (such as Xanax). These drugs target the GABA receptors in a similar way to CBD, but with a much stronger effect.   In as little as 2 weeks, the body will start to form a dependency to benzodiazepines. When this happens, the GABA receptors adapt to the drug in an attempt to restore balance. GABA receptors become hidden in order to reduce the effects of the drug.   If the drug is no longer used, we lose our ability to activate GABA (because we have fewer receptors available in response to the drug). The results of this are the same symptoms that prompted us to take it in the beginning — anxiety, and insomnia. We become reliant on having the drug in our system for us to avoid anxiety attacks.   In short, taking prescription anxiety medications is safe short-term, but beyond 2-weeks of use, they can have the opposite effect — causing severe panic attacks and anxiety as soon as the medications start to wear off.   Common prescription Anxiety Medications Include: Alprazolam (Xanax) Clonazepam (Klonopin) Chlordiazepoxide (Librium) Diazepam (Valium) Lorazepam (Ativan) Temazepam (Restoril) Triazolam (Halcion)   CBD is an excellent supplement for anxiety symptoms, but it works best when combined with other approaches as well. A targeted, multifaceted approach is always going to have a greater impact than any single therapy on its own — including CBD.   Here are some other steps you can take to mitigate your anxiety: Eat a balanced diet & avoid high-sugar or processed foods Identify the cause of your anxiety and take steps to reduce its impact Visit a counselor to work through underlying traumas Take other anxiety supplements alongside CBD oil (kava, L-theanine, magnesium) Prioritize your sleep (aim for at least 8 hours of uninterrupted sleep each night) Exercise regularly (even just 20 minutes per day has been shown to reduce anxiety levels) Practice meditation or yoga (aim for 10 – 30 minutes per day)     CBD Oil For Depression Depression is the most common mood disorder — affecting as many as 300 million people around the world each year, according to The World Health Organization.   There are a few different types of depression — characterized by the presence of other symptoms and the length of time the condition was present. All forms of depression involve chronically low-mood and motivation. Other symptoms may include fatigue, chronic pain, insomnia, anxiety, or low libido.   There Are Three Severity Levels of Depression: Mild depression — involving low-grade loss of interest or low motivation. Moderate depression — involves a major loss in motivation and low energy, and may or may not interfere with daily responsibilities. Severe depression — can include thoughts of suicide or complete loss of motivation.   The Benefits of CBD For Depression There are a few ways CBD can be used to alleviate depression. The most important is through CBD’s anti-inflammatory benefits — especially on neuroinflammation (inflammation in the brain). Inflammation is considered to be one of the most common causes of depression [24].   CBD also protects the hippocampus from damage — which is a region of the brain tasked with regulating mood and one of the first regions of the brain to show signs of damage in the minds of depressed individuals.   The benefits of CBD oil for depression include: Reduces brain inflammation Protects the brain from damage and degeneration Increases anandamide activity in the brain Regulates serotonin, dopamine, and norepinephrine Supports a healthy night of sleep     CBD Oil For Other Mood Disorders Mood disorders (also called affective disorders) are a collection of neurological conditions affecting our ability to regulate and maintain emotion.   There are many different kinds of mood disorders, and CBD works a little differently for each one.   CBD has the biggest impact on mood disorders underpinned by inflammatory or autoimmune disease, or in people experiencing hyperactivity with their moods — such as bipolar disorder or mania. For depressive disorders, CBD offers benefits for common side effects like insomnia or low energy.   What Causes Mood Disorders? Substance abuse Chronic stress Bereavement Medication side-effects Neurodegenerative disorders Nutritional deficiencies Genetic predisposition Post traumatic stress Chronic anxiety   Here are the most common types of mood disorders and how CBD may be able to help:   1. Bipolar Disorder Bipolar disorder is a neurological disorder involving extreme shifts in mood — going from periods of deep depression to euphoric mania and everything in between.   There’s no cure for bipolar disorder, and medications for the condition are often hit or miss in their effectiveness.   A large clinical trial is currently investigating the potential benefits of CBD as part of a treatment plan for bipolar individuals. Although the study isn’t scheduled to finish until 2020, the results are looking promising for CBD.   The Benefits of CBD For Bipolar Disorder CBD may be effective for bipolar disorder — however, bipolar disorder affects everyone differently. What might work on one person could make symptoms worse for another. So it’s important to discuss the use of CBD with your doctor or psychologist before giving it a try.   If you decide to use CBD, always start with the smallest dose possible and build up gradually from there to see how it affects your symptoms.     2. Mania Mania (also referred to as manic syndrome) is a serious condition involving abnormally high energy levels, feelings of euphoria, and frequent anxiety attacks. It’s the opposite of depression, but it can be just as debilitating.   Manic syndrome can lead to increased tendencies for violence, aggression, irritability, and delusions. This condition can be dangerous, causing people to become reckless and at a higher risk of injuries.   The Benefits of CBD For Mania Use CBD with extreme caution for mania due to concerns of worsening the condition. Mania is a severe condition that requires the care of trained medical professionals.   The cause of mania is different from one person to the next, and although there are reports of people using CBD to treat this symptom effectively — there are plenty of reports about cannabis products making symptoms worse as well.   3. Hypomania Hypomania is similar to mania but involves more mild symptoms. It’s somewhere between depression and mania.   Symptoms of hypomania involve extended periods of euphoria and disinhibition but aren’t as severe as mania.   The Benefits of CBD For Hypomania CBD can be used to support some of the side-effects of hypomania, such as insomnia and anxiety. Similarly to mania, CBD should be used cautiously with this condition. Always start with a small dose and increase gradually.   Once you know how it affects you individually and you’ve confirmed it doesn’t make symptoms worse, try increasing the dose.   4. Seasonal Affective Disorder (SAD) Seasonal affective disorder (SAD) is a mood disorder brought on by lack of sun exposure. It’s referred to as a seasonal disorder because it’s especially prevalent in northern climates during the winter months when daylight hours are at their lowest. At the same time, the cold weather in these places means the people living there tend to cover up most of their exposed skin — further limiting the exposure of UV light with the skin.   When light from the sun hits the skin, it drives an enzymatic reaction that produces vitamin D — a key regulator in our mood.   The best treatment for seasonal affective disorder is regular exposure to sunlight, or another source of UV light, and vitamin D supplementation.   The Benefits of CBD For Seasonal Affective Disorder (SAD) Both CBD and THC may be useful for this condition by alleviating many of the associated side-effects of the disorder such as insomnia, low immunity, depression, and anxiety. Vitamin D supplementation and UV light exposure are still required for maximum effect, however.   1. CANNAMi Broad Spectrum CBD Oil 500mg – Balance & Support Main Functions: Promote Natural Sleep Patterns and Improve Sleep Quality Relieve Pressure and Assist Emotional Management Reduce Chronic Pain and Inflammation Keep Your Body and Mind Healthy   2. CANNAMi Broad Spectrum CBD Oil 1000mg – Relief & Enhance Main Functions: Relieve Symptoms of Mild Depression, Anxiety and Mood Disorders Improve Insomnia and Sleep Quality Relieve Pressure and Assist Emotional Management Reduce Moderate Chronic Pain and Inflammation Keep Your Body and Mind Healthy   3. CANNAMi Broad Spectrum CBD Oil 1500mg – Extra Strength Main Functions: Relieve Symptoms of Depression, Anxiety and Mood Disorders Relieve Severe Insomnia and Regulates Sleep Cycle and Sleeping Patterns Relieve all kinds of Severe Pain and Inflammation Improve Skin Inflammation and Allergies, Promote Skin Repair Regulate the Brain to Reduce Seizures   4. CANNAMi Broad Spectrum CBG Oil 1000mg – Precision Soothing Main Functions: Effectively Improve and Relieve Appetite Problems Caused by Treatment of Critical Illness Relieves Symptoms of Depression, Anxiety and Mood Disorders Effective Treatment of Glaucoma Effective in Decreasing the Inflammation Characteristic of Inflammatory Bowel Disease Potent inhibitory effects on drug-resistant bacteria, such as staphylococcus bacteria Relieve chronic pain and inflammation   5. CANNAMi Broad Spectrum CBD Oil 500mg – Sleep Support Main Functions: ・Promote Natural Sleep Patterns and Improve Sleep Quality ・Relieve Pressure and Assist Emotional Management ・Relieve Chronic Pain and Inflammation ・Keep your Body and Mind Healthy   References Cited in This Article Manrique-Garcia, E., Zammit, S., Dalman, C., Hemmingsson, T., & Allebeck, P. (2012). Cannabis use and depression: a longitudinal study of a national cohort of Swedish conscripts. BMC Psychiatry, 12(1), 112. Banerjee, S. P., Snyder, S. H., & Mechoulam, R. A. P. H. A. E. L. (1975). Cannabinoids: influence on neurotransmitter uptake in rat brain synaptosomes. Journal of Pharmacology and Experimental Therapeutics, 194(1), 74-81. Réus, G. Z., Stringari, R. B., Ribeiro, K. F., Luft, T., Abelaira, H. M., Fries, G. R., … & Crippa, J. A. (2011). Administration of cannabidiol and imipramine induces antidepressant-like effects in the forced swimming test and increases brain-derived neurotrophic factor levels in the rat amygdala. Acta neuropsychiatrica, 23(5), 241-248. Campos, A. C., Moreira, F. A., Gomes, F. V., Del Bel, E. A., & Guimaraes, F. S. (2012). Multiple mechanisms involved in the large-spectrum therapeutic potential of cannabidiol in psychiatric disorders. Philosophical Transactions of the Royal Society B: Biological Sciences, 367(1607), 3364-3378. Zuardi, A. W., Cosme, R. A., Graeff, F. G., & Guimarães, F. S. (1993). Effects of ipsapirone and cannabidiol on human experimental anxiety. Journal of psychopharmacology, 7(1), 82-88. de Souza Crippa, J. A., Zuardi, A. W., Garrido, G. E., Wichert-Ana, L., Guarnieri, R., Ferrari, L., … & McGuire, P. K. (2004). Effects of cannabidiol (CBD) on regional cerebral blood flow. Neuropsychopharmacology, 29(2), 417. Hsiao, Y. T., Yi, P. L., Li, C. L., & Chang, F. C. (2012). Effect of cannabidiol on sleep disruption induced by the repeated combination tests consisting of open field and elevated plus-maze in rats. Neuropharmacology, 62(1), 373-384. Fusar-Poli, P., Allen, P., Bhattacharyya, S., Crippa, J. A., Mechelli, A., Borgwardt, S., … & Zuardi, A. W. (2010). Modulation of effective connectivity during emotional processing by Δ9-tetrahydrocannabinol and cannabidiol. International journal of neuropsychopharmacology, 13(4), 421-432. Crippa, J. A. S., Derenusson, G. N., Ferrari, T. B., Wichert-Ana, L., Duran, F. L., Martin-Santos, R., … & Filho, A. S. (2011). 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W., Goodman, W. K., & Heninger, G. R. (1987). Serotonin function in anxiety. Psychopharmacology, 92(1), 14-24. Zweifel, L. S., Fadok, J. P., Argilli, E., Garelick, M. G., Jones, G. L., Dickerson, T. M., … & Palmiter, R. D. (2011). Activation of dopamine neurons is critical for aversive conditioning and prevention of generalized anxiety. Nature neuroscience, 14(5), 620-626. Seeman, P. (2016). Cannabidiol is a partial agonist at dopamine D2High receptors, predicting its antipsychotic clinical dose. Translational psychiatry, 6(10), e920-e920. Bakas, T., Van Nieuwenhuijzen, P. S., Devenish, S. O., McGregor, I. S., Arnold, J. C., & Chebib, M. (2017). The direct actions of cannabidiol and 2-arachidonoyl glycerol at GABAA receptors. Pharmacological research, 119, 358-370. Rossi, S., Studer, V., Motta, C., Polidoro, S., Perugini, J., Macchiarulo, G., … & Furlan, R. (2017). Neuroinflammation drives anxiety and depression in relapsing-remitting multiple sclerosis. Neurology, 89(13), 1338-1347. 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2021-02-25

CBD對睡眠的好處

CBD 對睡眠的好處 CBD 有很多好處,但對其支持健康睡眠的作用研究卻很少。 最佳的 CBD 睡眠油由全光譜或廣譜漢麻提取物製成,並通過第三方測試證明其純度,並提供其他成分來增強CBD的鎮靜性。 以下是五種基於證據的機制, CBD 使用這些機制來提高我們入睡,維持睡眠的能力,並在第二天早晨使您感到更加放鬆。   1. CBD 的鎮靜作用 高劑量 CBD 最常觀察到的作用之一是鎮靜[ 4 ]。 CBD 不僅有助於改善整體睡眠質量,而且還有助於改善持續時間[ 5 ]。 在較低劑量下, CBD 已顯示出相反的效果-支持清醒和注意力[ 11 ]。 服用 CBD 油時必須使用劑量範圍的高端,以便利用鎮靜劑的質量(更多有關以後如何服用 CBD 油的信息)。 還顯示出其他幾種大麻素具有鎮靜作用,例如 CBN , CBG , CBC 和 CBDV 。這就是為什麼最好使用全光譜或廣譜提取物而不是 CBD 隔離油睡眠。   2. CBD 可以緩解焦慮 壓力引起的焦慮會導致睡眠模式中斷。 CBD 已顯示可減輕壓力和焦慮症狀[ 6 ]。 結合其他壓力管理技術, CBD 可能是減輕焦慮症狀的有用補充,可幫助您在一天結束時更輕鬆地入睡。   3. CBD 可能減少惡夢 如果噩夢或倒敘使您徹夜難眠,臨床試驗表明CBD可以停止或顯著減少噩夢和持久性記憶[ 7 ]。 人們還不太了解 CBD 如何提供這種好處,但這是使用 CBD 的普遍報導的好處。許多父母報告說,對患有夜驚的較小兒童使用 CBD 時,情況有所改善。   4. CBD 可能會改善睡眠方式 CBD 已對患有 REM 睡眠行為障礙的人顯示出令人鼓舞的結果,這種疾病會導致人們在REM睡眠期間表現出身體不適。 還發現可以通過增加總睡眠時間來支持白天過度嗜睡的人[ 8 ]。 CBD 可以幫助重置睡眠方式,並延長睡眠時間。   5. CBD 可能減輕疼痛 慢性疼痛是睡眠障礙的最常見原因之一。 CBD 可以緩解您入睡時的疼痛。 許多患者報告了用 CBD 代替處方止痛藥,尤其是在治療頭痛,纖維肌痛,關節炎和其他慢性疼痛綜合症方面。 甚至有證據表明, CBD 可用於幫助人們戒除鴉片/阿片類藥物或苯二氮類藥物,並減輕戒斷症狀[ 9 ]。     1. CANNAMi CBD廣譜油 500mg – 平衡保健配方 主要功效: 促進自然睡眠規律,改善睡眠質素 紓緩生活壓力及協助情緒管理 減輕慢性疼痛和炎症 保持身體和心靈平衡健康   2. CANNAMi CBD廣譜油 1000mg – 舒緩提升配方 主要功效: 緩和輕度抑鬱、焦慮和情緒障礙症狀 趕走失眠因子,改善睡眠質素 紓緩生活壓力及協助情緒管理 減輕中度慢性疼痛和炎症 保持身體和心靈平衡健康   3. CANNAMi CBD廣譜油 1500mg – 全效強力配方 主要功效: 緩和抑鬱、焦慮和情緒障礙症狀 紓緩嚴重失眠,調節睡眠週期和方式 紓緩各項嚴重疼痛和炎症 改善皮膚發炎及過敏、促進皮膚修復 調節大腦減少癲癇發作   4. CANNAMi CBG廣譜油 1000mg – 精準舒緩配方 主要功效: 有效改善及舒緩因治療頑疾後所引致的食慾問題 紓緩抑鬱、焦慮和情緒障礙症狀 有效治療青光眼 有效減少炎症性腸病的炎症特徵 有效抑製耐藥性細菌, 如金黃色葡萄球菌 減輕慢性疼痛和炎症   5. CANNAMi CBD廣譜油 500mg – 舒壓安眠配方 主要功效: 促進自然睡眠規律,改善睡眠質素 紓緩情緒壓力及協助情緒管理 減輕慢性疼痛和炎症 保持身體和心靈平衡健康     References Cited In This Article Watson, N. F., Badr, M. S., Belenky, G., Bliwise, D. L., Buxton, O. M., Buysse, D., … Tasali, E. (2015). Recommended Amount of Sleep for a Healthy Adult: A Joint Consensus Statement of the American Academy of Sleep Medicine and Sleep Research Society. Sleep, 38(6), 843–4. https://doi.org/10.5665/sleep.4716 Murillo-Rodriguez, E., Pastrana-Trejo, J. C., Salas-Crisóstomo, M., & de-la-Cruz, M. (2017). The Endocannabinoid System Modulating Levels of Consciousness, Emotions, and Likely Dream Contents. CNS & Neurological Disorders – Drug Targets, 16(4). https://doi.org/10.2174/1871527316666170223161908 Mendiguren, A., Aostri, E., & Pineda, J. (2018). Regulation of noradrenergic and serotonergic systems by cannabinoids: relevance to cannabinoid-induced effects. Life Sciences, 192, 115–127. https://doi.org/10.1016/j.lfs.2017.11.029 Crippa, J. A., Guimarães, F. S., Campos, A. C., & Zuardi, A. W. (2018). Translational Investigation of the Therapeutic Potential of Cannabidiol (CBD): Toward a New Age. Frontiers in Immunology, 9. https://doi.org/10.3389/FIMMU.2018.02009 Russo, E. B., Guy, G. W., & Robson, P. J. (2007, August 1). Cannabis, pain, and sleep: Lessons from therapeutic clinical trials of sativexρ, a cannabis-based medicine. Chemistry and Biodiversity. Wiley-Blackwell. https://doi.org/10.1002/cbdv.200790150 Blessing, E. M., Steenkamp, M. M., Manzanares, J., & Marmar, C. R. (2015, October). Cannabidiol as a Potential Treatment for Anxiety Disorders. Neurotherapeutics. Springer. https://doi.org/10.1007/s13311-015-0387-1 Jetly, R., Heber, A., Fraser, G., & Boisvert, D. (2015). The efficacy of nabilone, a synthetic cannabinoid, in the treatment of PTSD-associated nightmares: A preliminary randomized, double-blind, placebo-controlled cross-over design study. Psychoneuroendocrinology,51, 585–588. https://doi.org/10.1016/j.psyneuen.2014.11.002 Babson, K. A., Sottile, J., & Morabito, D. (2017). Cannabis, Cannabinoids, and Sleep: a Review of the Literature. Current Psychiatry Reports, 19(4), 23. https://doi.org/10.1007/s11920-017-0775-9 Baron, E. P., Lucas, P., Eades, J., & Hogue, O. (2018). Patterns of medicinal cannabis use, strain analysis, and substitution effect among patients with migraine, headache, arthritis, and chronic pain in a medicinal cannabis cohort. The Journal of Headache and Pain, 19(1), 37. https://doi.org/10.1186/s10194-018-0862-2 WHO. (2017). WHO | Cannabidiol (compound of cannabis). WHO. Retrieved from http://www.who.int/features/qa/cannabidiol/en/ Murillo-Rodríguez, E., Millán-Aldaco, D., Palomero-Rivero, M., Mechoulam, R., & Drucker-Colín, R. (2006). Cannabidiol, a constituent of Cannabis sativa, modulates sleep in rats. FEBS letters, 580(18), 4337-4345.        
2021-02-23

內源性大麻素系統和 CBD 指南

  諸如 CBD 和 THC 的大麻素的發現刺激了對這些分子對人體的益處以及它們表現這些作用方式的研究。在發現稱為內源性大麻素系統(ECS)的廣泛的細胞受體網絡後,終於找到了缺失的難題。 這一突破性發現不僅幫助科學家弄清了大麻素的工作原理,而且還闡明了複雜的生理系統,可以說這是人類最重要的神經化學網絡。 今天,我們為所有想要了解 CBD 和 THC 如何對人體產生影響的人準備了一個內源性大麻素系統的簡短指南。 首先讓我們重點介紹 ECS 的主要組成部分。   內源性大麻素系統的組成 所述內源性大麻素系統由三個關鍵因素:內源性大麻素,受體,和酶。   內源性大麻素 這些化合物由 ECS 天然產生,並在體內合成以向 ECS 受體發出信號。Endo 來自希臘語,意思是“內部”,其中大麻素是指激活這些受體的分子。體內的兩個主要內源性大麻素是 2-AG 和 anandamide (1)。   大麻受體( CB1 和 CB2 ) 該內源性大麻素系統有兩種類型的受體: CB1 和 CB2 。這些結合位點存在於全身所有器官系統和許多細胞類型中。不同的大麻素可以激活,抑製或調節大麻素受體的活性。這是真實的兩個內源性大麻素,phytocannabinoids (來自植物),並在實驗室中製成合成大麻素。研究人員還認為, TRPV1 (瞬態受體電位類香草)是 ECS 的一部分,因為它是 CBD , THC 和 anandamide 的結合位點。   酵素 酶是分解體內某些化學物質以催化化學反應的蛋白質。該內源性大麻素系統產生的酶,這兩個構建和代謝大麻素。脂肪酸酰胺水解酶(FAAH)是 ECS 中的主要酶之一,可分解 anandamide 。   什麼是大麻素受體及其作用   大麻受體是內源性大麻素系統的重要組成部分。當它們接收來自內源性大麻素的信息時,會在細胞之間以及從細胞外部到內部之間傳遞它們,從而使這些神經遞質表現出它們對身體和大腦的作用。   CB1 受體在哪裡? CB1 受體雖然在許多其他地區也可以找到,但大部分都在大腦和神經系統中找到。到目前為止,研究人員已經在人體以下區域發現了CB1受體:  腦 脂肪細胞 胃腸道 肝 胰腺 生殖器官 骨骼肌 脊髓   CB2 受體在哪裡? 儘管研究程度低於 CB1 受體,但 CB2 受體出現在體內的區域較少。它們主要存在於免疫系統中,也存在於皮膚中。研究人員在以下方面鑑定出CB2受體: 骨 脂肪細胞 胃腸道 免疫系統 肝 生殖器官   人們為什麼有大麻素受體? 大麻受體存在於全身許多細胞類型的膜中。它由兩個空間組成-細胞外(細胞外部)和細胞內(內部)。當大麻素與大麻素受體結合時,它會向細胞內部發送信號,從而改變其功能。受體的激活位置通常表明其影響的功能。 大麻受體充當細胞外空間和細胞內部之間的中間人。激活後,大麻素受體會導致細胞改變其活性並導致向體內穩態的集體轉變-一種內部平衡狀態。   內源性大麻素系統的作用是什麼? 大麻研究人員已將內源性大麻素系統定義為穩態調節劑(2)。換句話說,ECS確保其他進程在沒有任何干擾的情況下運行。神經元利用突觸空間將大麻素向後發送到受體,以管理他們想要接收的分子(3)。 體內平衡的一個典型例子是體溫。如果峰值過高或下降過低,則物理功能將無法正常運行。我們的身體一直在努力保持 36-37 C 的安全範圍。 我們所有的生理系統都在恆定的平衡狀態下運作,內源性大麻素可根據需要幫助調節這種狀態。所述內源性大麻素系統演示了在以下系統(4)的調節作用: 中樞和周圍神經系統 內分泌系統 免疫系統 代謝   CBD如何與內源性大麻素系統相互作用?   CBD 油中的植物大麻素在內源性大麻素系統中具有不同的相互作用機理。 CBD 對 CB1 和 CB2 受體的結合親和力很低。事實是,與低劑量的四氫大麻酚一起服用時, CBD 可抑制 CB1 受體(5)。因此, CBD 沒有令人陶醉的特性-它不會使您高昂。 除此之外, CBD 還與 TRPV1 受體結合, TRPV1 受體是部分參與內源性大麻素系統信號傳導的位點。激活該受體會根據觸發因素影響不同的生理過程。 服用 CBD 油時, CBD 還可以通過增加 anandamide 的濃度間接刺激 CB1 和 CB2 受體。那是因為大麻素會抑制 FAAH 酶,否則該酶會分解 anandamide  。此功能使 CBD 的 anandamide 再攝取抑製劑。 隨著對 CBD 對健康益處的研究不斷擴展,育種者正在投入大量時間開發富含 CBD 的大麻菌株,以滿足消費者的需求。 在大麻的非精神活性表親工業大麻植物的花朵中也可以發現高濃度的 CBD 。   THC 如何與內源性大麻素系統相互作用? THC 在分子結構上與 anandamide 極為相似,從而使其能夠結合併激活 CB1 和 CB2 受體。 直到最近,由於其產生的特徵性大麻高,育種者一直致力於生產富含四氫大麻酚的菌株。 THC 對大腦中 CB1 受體的親和力可實現這種精神狀態的改變,從而導致多巴胺水平的增加,欣快的情緒,食慾的增加以及除其他生理變化之外的深度放鬆。 但是, THC 和 anandamide 僅部分刺激 CB1 受體。研究人員還發明了一種合成形式的四氫大麻酚,可以活化整個部位,但常常會引起不愉快的程度,從而引發妄想症和恐慌症。 THC 也是 CB2 受體的部分激動劑。   如何維持內源性大麻素系統的正常運作 該內源性大麻素系統是典型的人類保持生理平衡。但是,有時內在大麻素系統的功能可能會受到多種因素的影響。研究人員建議,每個人都有最佳的“內源性大麻素”,這是指體內產生並流通的足夠量的大麻素。 大麻素含量不足可能會觸發一種稱為臨床內源性大麻素缺乏症(CECD)的疾病(6)。研究人員稱,臨床上內源性大麻素缺乏可能是偏頭痛, PTSD ,纖維肌痛,神經性疼痛和一系列自身免疫性疾病的根本原因。 那麼,您如何才能支持您的內源性大麻素系統,使其永不過時? 以下是一些簡單(免費)的提示: 補充大麻素:如前所述,諸如 CBD 和 THC 的大麻素與 ECS 中的大麻素受體相互作用。越來越多的科學證據支持大麻的許多治療用途。大麻素是低內源性大麻素音調的首選治療方法。 有氧運動:跑步和騎自行車等活動可能是提高大腦中 anandamide 水平的良好方法。也被稱為“跑步者的高,”你完成了運行後遇到的興奮 sesh 歸因於水平的提高大麻素在大腦(7)。這將解釋“ anandamide ”的含義,在梵文中將其翻譯為“幸福”。 歐米茄脂肪酸:只有存在足夠的歐米茄3脂肪酸,才能合成大麻素(8)。富含 omega-3 的食物包括肉,魚,大麻籽,核桃和魚子醬。 萜烯:一些萜烯,例如月桂烯或石竹烯,可以增強大麻素的作用,增強內源性大麻素系統。例如,月桂烯可確保大麻素更好地滲透血腦屏障。反過來,石竹烯直接與 CB2 受體結合,幫助身體舒緩神經並改善情緒(9)。萜烯存在於所有草藥,香料,水果和蔬菜中;它們還負責植物的香氣和風味。   ECS:這是一個新的主系統嗎? 該內源性大麻素系統是最重要的我們的福祉。它不僅是人體最大的神經化學網絡,而且還調節著所有其他器官系統的活動。正常運作的內源性大麻素系統可確保主要生物學過程之間的內部平衡,包括記憶,情緒加工,認知,感官知覺,繁殖,體溫,免疫功能等。 儘管內源性大麻素系統是一個相對較新的發現,但仍進行了新的研究以探索其機制以及刺激 ECS 有助於解決各種健康問題的方式。我們期待著這方面的未來發現。 目前,我們只想強調一件事:照顧您的 ECS 只是一個聰明的主意。最好的支持方式是通過有機大麻來源的高質量,經過實驗室測試的 CBD 產品。   參考文獻: EB,Russo,“內源性大麻素系統簡介”,取自:https://www.phytecs.com/wp-content/uploads/2015/02/IntroductionECS.pdf 阿查里亞(Acharya),南迪尼(Nandini)等。“內源性大麻素系統可調節腸道免疫穩態。” 美國國家科學院院刊。114,19(2017):5005-5010。doi:10.1073 /pnas.1612177114 Kreitzer ,Anatol C和Wade G Regehr 。“通過內源性大麻素逆行信號。” 神經生物學的最新觀點。12,3(2002):324-30。doi:10.1016 / s0959-4388(02)00328-8 科莫羅夫斯基,揚和亨里克·史泰平。“羅拉układu endokannabinoidowego W¯¯ regulacji czynności dokrewnej我kontroli równowagi energetycznej człowieka ”[中的作用,內源性大麻素系統,內分泌功能的調節,並在人體能量平衡的控制。Postepy higieny i medycyny doswiadczalnej (在線)第一卷。61(2007):99-105。 Russo,Ethan B和Jahan Marcu 。“大麻藥理學:通常的嫌疑人和一些有希望的線索。” 藥理學進展(加利福尼亞聖地亞哥)。80(2017):67-134。doi:10.1016 /bs.apha.2017.03.004 Ethan B. Russo,“重新考慮了臨床內源性大麻素缺乏症:目前的研究支持偏頭痛,纖維肌痛,腸易激綜合徵和其他耐治療綜合徵的理論。” 大麻和大麻素研究卷。1,1 154-165。2016年7月1日,doi :10.1089 /can.2016.0009 福斯,約翰內斯等。“跑步者的高水平取決於小鼠中的大麻素受體。” 美國國家科學院院刊。112,42(2015):13105-8。doi:10.1073 /pnas.1514996112 沃森,約瑟芬E等。“新興的omega-3脂肪酸內源性大麻素及其衍生物。” 前列腺素及其他脂類介質卷。143(2019):106337. doi:10.1016 /j.prostaglandins.2019.106337 Bahi ,Amine等。“β-石竹烯,CB2受體激動劑會產生與小鼠焦慮和抑鬱相關的多種行為變化。” 生理與行為卷 135(2014):119-24。doi:10.1016 /j.physbeh.2014.06.003     1. CANNAMi CBD廣譜油 500mg – 平衡保健配方 主要功效: 促進自然睡眠規律,改善睡眠質素 紓緩生活壓力及協助情緒管理 減輕慢性疼痛和炎症 保持身體和心靈平衡健康   2. CANNAMi CBD廣譜油 1000mg – 舒緩提升配方 主要功效: 緩和輕度抑鬱、焦慮和情緒障礙症狀 趕走失眠因子,改善睡眠質素 紓緩生活壓力及協助情緒管理 減輕中度慢性疼痛和炎症 保持身體和心靈平衡健康   3. CANNAMi CBD廣譜油 1500mg – 全效強力配方 主要功效: 緩和抑鬱、焦慮和情緒障礙症狀 紓緩嚴重失眠,調節睡眠週期和方式 紓緩各項嚴重疼痛和炎症 改善皮膚發炎及過敏、促進皮膚修復 調節大腦減少癲癇發作   4. CANNAMi CBG廣譜油 1000mg – 精準舒緩配方 主要功效: 有效改善及舒緩因治療頑疾後所引致的食慾問題 紓緩抑鬱、焦慮和情緒障礙症狀 有效治療青光眼 有效減少炎症性腸病的炎症特徵 有效抑製耐藥性細菌, 如金黃色葡萄球菌 減輕慢性疼痛和炎症   5. CANNAMi CBD廣譜油 500mg – 舒壓安眠配方 主要功效: 促進自然睡眠規律,改善睡眠質素 紓緩情緒壓力及協助情緒管理 減輕慢性疼痛和炎症 保持身體和心靈平衡健康    
2021-02-21

什麼是 CBD 的健康益處?

據報導,CBD 有許多好處-從減輕疼痛和發炎一直到保護大腦免受神經退行性疾​​病。CBD 油和其他 CBD 產品的化合物對平衡體內有很多好處的效果。 CBD 的主要好處包括: 減輕慢性疼痛和炎症 改善睡眠質量 緩解慢性壓力和焦慮 調節情緒和抑鬱 支持免疫功能 保護大腦免受神經退行性疾​​病 促進皮膚健康 緩解與關節炎有關的慢性關節痛 加快鍛煉之間的肌肉恢復     1. CANNAMi CBD廣譜油 500mg – 平衡保健配方 主要功效: 促進自然睡眠規律,改善睡眠質素 紓緩生活壓力及協助情緒管理 減輕慢性疼痛和炎症 保持身體和心靈平衡健康   2. CANNAMi CBD廣譜油 1000mg – 舒緩提升配方 主要功效: 緩和輕度抑鬱、焦慮和情緒障礙症狀 趕走失眠因子,改善睡眠質素 紓緩生活壓力及協助情緒管理 減輕中度慢性疼痛和炎症 保持身體和心靈平衡健康   3. CANNAMi CBD廣譜油 1500mg – 全效強力配方 主要功效: 緩和抑鬱、焦慮和情緒障礙症狀 紓緩嚴重失眠,調節睡眠週期和方式 紓緩各項嚴重疼痛和炎症 改善皮膚發炎及過敏、促進皮膚修復 調節大腦減少癲癇發作   4. CANNAMi CBG廣譜油 1000mg – 精準舒緩配方 主要功效: 有效改善及舒緩因治療頑疾後所引致的食慾問題 紓緩抑鬱、焦慮和情緒障礙症狀 有效治療青光眼 有效減少炎症性腸病的炎症特徵 有效抑製耐藥性細菌, 如金黃色葡萄球菌 減輕慢性疼痛和炎症   5. CANNAMi CBD廣譜油 500mg – 舒壓安眠配方 主要功效: 促進自然睡眠規律,改善睡眠質素 紓緩情緒壓力及協助情緒管理 減輕慢性疼痛和炎症 保持身體和心靈平衡健康  
2021-02-21

CBD 101 : CBD 是什麼?

大麻二酚(Cannabidiol,CBD)是漢麻百多隻有效成分中最具醫療價值的一種,有放鬆身心、保護神經、改善皮膚發炎、抗氧化、舒緩皮膚敏感泛紅、為皮膚表層建立保護屏障、改善皮膚自我修復力;對恢復皮膚健康、舒緩皮膚問題的能力,可以治療濕疹等病。 大麻二酚(CBD)是天然漢麻的主要非精神科成分,不會令人興奮上癮,是合法、安全,並具有多種藥理作用,包括抗焦慮、抗精神病、止吐和抗炎特性。該綜述根據 Web of Science,Scielo 和 Medline 檢索的報告描述了廣泛濃度 CBD 給藥的多項研究表明,CBD 在非轉化細胞中無毒性,不會誘發食物攝入變化,不會誘發全身僵硬症,不會影響生理參數(心率、血壓和體溫),不會影響胃腸道的轉運和不會改變精神運動或心理功能。   觀看精神科專科醫生介紹片段:   研究報告指出,長期使用和高劑量 (高達1500毫克/天) 的 CBD 在人體內耐受性仍然良好。儘管 CBD 與 THC 具有分子相似性,CBD 僅在非常高劑量(THC 的100倍)下才與大麻素受體有相互弱作用性。另外,在 CBD 中亦未察覺到如 THC 般會引起對人體思維和感知的改變。不同藥理學性質使 CBD 與 THC 具有完全不一樣的安全性。 對25項關於生物多樣性公約內安全性和功效研究的綜述,並未發現 CBD 於廣泛劑量範圍中使用多種給藥方式有顯著副作用,包括急性和慢性給藥方案。CBD已在歐洲大部分地區和其他國家獲得安全性和功效批准。因此,有關它的新陳代謝,毒理學和安全性巳在醫學上具有廣泛的信息。   1. CANNAMi CBD廣譜油 500mg – 平衡保健配方 主要功效: 促進自然睡眠規律,改善睡眠質素 紓緩生活壓力及協助情緒管理 減輕慢性疼痛和炎症 保持身體和心靈平衡健康   2. CANNAMi CBD廣譜油 1000mg – 舒緩提升配方 主要功效: 緩和輕度抑鬱、焦慮和情緒障礙症狀 趕走失眠因子,改善睡眠質素 紓緩生活壓力及協助情緒管理 減輕中度慢性疼痛和炎症 保持身體和心靈平衡健康   3. CANNAMi CBD廣譜油 1500mg – 全效強力配方 主要功效: 緩和抑鬱、焦慮和情緒障礙症狀 紓緩嚴重失眠,調節睡眠週期和方式 紓緩各項嚴重疼痛和炎症 改善皮膚發炎及過敏、促進皮膚修復 調節大腦減少癲癇發作   4. CANNAMi CBG廣譜油 1000mg – 精準舒緩配方 主要功效: 有效改善及舒緩因治療頑疾後所引致的食慾問題 紓緩抑鬱、焦慮和情緒障礙症狀 有效治療青光眼 有效減少炎症性腸病的炎症特徵 有效抑製耐藥性細菌, 如金黃色葡萄球菌 減輕慢性疼痛和炎症   5. CANNAMi CBD廣譜油 500mg – 舒壓安眠配方 主要功效: 促進自然睡眠規律,改善睡眠質素 紓緩情緒壓力及協助情緒管理 減輕慢性疼痛和炎症 保持身體和心靈平衡健康                
2021-02-21